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Cortical thickness, subcortical deformation, and structural covariance networks in youth with perinatally-acquired HIV: associations with HIV disease severity and cognition

PI: C. Paula Lewis de los Angeles, F30 Predoctoral NRSA

Summary:
This project uses structural MRI data from youth with perinatally-acquired HIV (PHIV) in combination anti-retroviral therapy (cART) to characterize neuro-structure and structural covariance networks and its correlation to HIV disease severity and cognitive performance.

Papers:

• Deformed subcortical structures are related to past HIV disease severity in youth with perinatally acquired HIV infection.
  Lewis-de los Angeles, CP, Alpert, KI, Williams, PL, Malee, K, Huo, Y, Csernansky, JG, Yogev, R, Van Dyke, RB, Sowell, ER, Wang, L for the Pediatric HIV/AIDS Cohort Study (PHACS)
  Journal of the Pediatric Infectious Diseases Society 2016; 5: S6-S14
  View Article
  

Funding:

• NICHD: NRSA F30: Cortical thickness, subcortical deformation, and structural covariance networks in youth with perinatally-acquired HIV: associations with HIV disease severity and cognition (PI: de los Angeles) - C. Paula Lewis-de los Angeles was awarded an NRSA F30 Predoctoral Fellowship for MD/PhD students from the NIH Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD). The project focuses on characterizing brain morphology and networks in youth with perinatally-acquired HIV using neuroimaging. The fellowship will support research and clinical training. (12/01/2016 - 12/01/2018).