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MDD Marker using Rat Imaging

PI: Eva Redei, PhD, Wang

Summary:
Using translational approach, we develop blood and brain imaging markers for major depression in a genetic rat model, and validate their integration in patients with recurrent early onset major depression.

Funding:

• Ken and Ruth Davee Award for Innovative Investigations in Affective Disorders: Neuroimaging Pilot Study Using an Animal Model of Major Depression (PI: Lei Wang, Eva Redei) - We analyze structural and resting-state functional magnetic resonance (MR) scans and behaviors of a rat model of depression that Dr. Redei has developed (i.e.,Wistar Kyoto More Immobile, or WMI) and controls. The overall goal is to provide additional, critical preliminary data to demonstrate our ability to provide neuroimaging measures that can be used to associate with transcripts of the same abundance differences in brain regions and the blood of WMI rats (to be obtained from other, ongoing studies). (09/01/2012 - 08/31/2013).